Posts Tagged ‘ABC News’

More Hope for Melanoma Patients in a Year of Milestones

Wednesday, August 24th, 2011

Treatment options for melanoma have advanced in the past year with heartening results.  As we wrote in March 2011, the drug Yervoy (ipilimumab or “ipi”) appears to be successful for a small group of patients with inoperable, metastatic melanoma in extending survival.  In fact, WebMD says that “Yervoy … is the first drug ever shown to help late-stage melanoma patients live longer.”

Now, there’s more news to be hopeful about on the pharma front with potentially greater results: The FDA has also given the go-ahead to a drug called ZELBORAF (vemurafenib, pronounced vem-yoo-RAF-en-ib).   A comprehensive overview by ABC News offers a clear explanation of how Zelboraf attacks a genetic mutation (known as BRAF V600E) which is found in about half of melanoma patients, inhibiting the disease’s ability to spread.

We now have the capability to analyze a patient’s melanoma tumor for the genetic mutation BRAF and use the targeted treatment Zelboraf to attack the tumor, shrink it and stop the progression of this deadly disease,” said Dr. Anna Pavlick, director of the NYU Melanoma Program at the NYU Cancer Institute, who has been involved in clinical trials for Zelboraf. …Zelboraf shuts down the abnormal signals of the tumor cells that are caused by the genetic mutation and stops the cells from dividing, without affecting healthy cells.

At the same time, the FDA approved a genetic test to determine if patients carry the mutation since only those with the abnormal “BRAF” gene can take Zelboraf.  Interestingly, since the same genetic mutation is found in those with other forms of cancer, there may be future help from this drug beyond skin cancer and is now, for example, being tested on thyroid cancer patients.

This is the fastest the FDA has ever approved a drug to come to market – in just five years.  And even better: Zelboraf, which is a first-in-class drug, is anticipated to be available in the next two weeks.

There are differences between Yervoy and Zelboraf.   As described in the coverage by the SF Chronicle,

Yervoy was found to extend patients’ lives, an improvement over many current treatments. However, the drug works for less than 20 percent of patients, and doctors say they can’t predict which patients will find it most effective.

Zelboraf was clinically effective in 50 percent of patients [with the] specific genetic mutation … Most of the therapies for melanoma work for less than 20 percent of patients, and some fall into single digits.

Neither Zelboraf nor Yervoy cure melanoma.  And as a patient who had great success in a clinical trial for the new drug said, “there’s nothing that says this medication will help you forever.”  But these drugs bring hope for a longer life, and as new therapies come along the melanoma pipeline, there is reason to be optimistic.

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There’s an App – and a list – for that Sunscreen

Monday, June 6th, 2011

Note:  Since we posted the below entry, good news: the FDA has now announced their new guidelines which will include mandatory labeling by the summer of 2012.  Here’s an excellent overview from ABC:

In the meantime, please remember to review your choices, and keep applying that sunscreen!

The Environmental Working Group’s guide to effective and less-toxic or non-toxic sunscreens is out again with additional options on this 2011 version. This comprehensive list, and associated articles, does an excellent job of explaining the challenges with both the FDA’s progress in setting standards for sun-protection products…and consumers’ understanding of the elements that go into that sunscreen — good or bad.

Even since we shared their 2010 list last May, more outcry has been heard about a common ingredient in many mainstream sunscreens, that is a derivative of Vitamin A: Retinyl palmitate.  In fact, in June of last year, Senator Chuck Schumer called on the FDA to investigate it, as mentioned in this release from his office:

Retinyl palmitate is an ingredient found in most of the 500 most popular sunscreen products. Scientists at both the NCTR and the NTP have been working diligently over the last decade at the FDA’s request in order to determine whether this Vitamin A derivative, retinyl palmitate, is safe to use in sunscreen products. In one study, tumors and lesions developed up to 21 percent faster in lab animals coated in retinyl palmitate-laced cream than animals treated with a cream that did not contain RP. While these studies have been completed for almost a year now, the FDA has not issued an assessment of ruling on either of them….

Schumer added, “Millions of Americans use sunscreen to keep themselves and their families protected from the dangers of too much sun. If the product they are using is doing more harm than good, they have a right to know.”

Of course, there is NO safe way to TRY to tan, just as the American Academy of Dermatology says. But in tan PREVENTION, there are things to consider.  Here’s something from a section on their Website about sunscreen, that you might not have known:

Q: When should sunscreen be used?
A: Sunscreen should be applied every day to exposed skin, and not just if you are going to be in the sun. UVB rays cannot penetrate glass windows, but UVA rays can, leaving you prone to these damaging effects if unprotected.

For days when you are going to be indoors, apply sunscreen on the areas not covered by clothing, such as the face and hands. Sunscreens can be applied under makeup, or alternatively, there are many cosmetic products available that contain sunscreens for daily use. Sun protection is the principal means of preventing premature aging and skin cancer. It’s never too late to protect yourself from the sun and minimize your future risk of skin cancer.

Don’t reserve the use of sunscreen only for sunny days. Even on a cloudy day, up to 80 percent of the sun’s ultraviolet rays can pass through the clouds. In addition, sand reflects 25 percent of the sun’s rays and snow reflects 80 percent of the sun’s rays.

So, as the inquiry continues, we, again, are of the belief that smart skin cancer prevention tactics start with covering up and include generous use of sunscreen. Of those, perhaps making a more natural choice of mineral (titanium dioxide, for example) vs non-mineral protection is a better option.  The  introductory paragraph to the Environmental Working Group’s guide says it all:

The best sunscreen is a hat and a shirt. No chemicals to absorb through the skin, no questions about whether they work. But when you can’t get away from exposing your skin to the sun, use EWG’s top-rated sunscreens to provide broad-spectrum (UVA and UVB-sunburn) protection with fewer hazardous chemicals that penetrate the skin. Sunscreen and sunblock makers are awaiting FDA approval for a wider selection of UVA-blocking chemicals. In the meantime, all [the Guide's] top-rated products contain either zinc or titanium minerals to help cut UVA exposures for sunscreen users.

PS: And now, yes, “there’s an app for that.”  EWG Sunscreen Buyer's Guide for iPhone, iPod touch, and iPad on the iTunes App Store_1307304366893The EWG Sunscreen guide reviews some 1700 products, so keeping them straight at the point of purchase will be easier for iPhone owners now.  Check it out in iTunes app store, for free.   

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A Lighthearted Look at Dark Tans May Help

Tuesday, April 27th, 2010

The tanning bed culture is still, sadly, alive and hard to quell.

A new study released as shared by ABCNews says that "Increased regulation and warnings about the dangers of habitual tanning have not curbed visits to tanning booths, much to the chagrin of doctors and public health advocates,” and may even be "addictive” in some people.

The NY Daily News goes on to explain that "though the research did not definitively prove that tanning is an addiction, some researchers think that, for some people, it can be:

… In the study, 421 students were questioned about their tanning habits. Some 229 of the students used indoor tanning beds. In this group, some 30 to 40 percent met the psychiatric diagnostic criteria for addiction (depending on the scale that was used). The tanners in this group also reported higher use of marijuana, alcohol and other substances, and more anxiety symptoms. Dr. James Spencer, spokesman for the American Academy of Dermatology, told ABC News the study was “an eye opener.” “We think that tanning gives a brief cosmetic change for a lifetime of problems with skin cancer and wrinkles,” he said.

However, there’s good news and bad news from Hollywood on trademark tans.

In another story from NYDailyNews.com, a visual exposé of "Tanorexics” as they were called, shows that many celebs are opting for self-tanners, eschewing the skin-aging, sun-baking version.  ’Tanorexics’

That’s the good news.

The bad news is:

a) they are still fighting to achieve that look at all and

b) some of them are doing it, well, pretty poorly – the worst of them even earning

’Oompa Loompa’ is Not a Good Look for Skin

titles like "Oompa Loompas” or

"radioactive.”

As NYDailyNews.com also says, "tons of stars are sporting some seriously over-the-top tans.”

“Oompa Loompa” is Not a Good Look for Skin

We are heartened that the publication is taking blatant sides, and even heartthrobs are fair game. Captions like this may help move the needle on popularity more to the side of natural pale:

“New York city hotelier Andre Balazs may have been named one of GQ’s Top Ten Most Stylish Men in America, but his summer color is so last season.”

or:

“Las Vegas” actress Molly Sims is one gorgeous girl – but even a Sports Illustrated Swimsuit model can’t pull off the leathery look.”

Let’s hear it for the sunless goddesses like Bebe Neuwirth or Kate Winslet. Bebe Neuwirth

kate winsletFor more inspiration, you can even see Listal’s top 60 "Pale Actresses”!



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