Archive for the ‘Science and Studies’ Category

Uncovering Sun Protection News

Sunday, August 29th, 2010

Where has the summer gone?  Well, in advance of what may be the last hurrah for some with Labor Day weekend approaching, here’s one more reminder that beach umbrellas are not foolproof protection.

Researchers from the University of Valencia found that 34% of ultraviolet radiation filters through under beach umbrellas. The umbrellas catch almost all of the direct rays but not the diffused radiation that penetrates through from the sides.

Beah Umbrella

While you’ll read a lot about melanoma awareness, prevention and early detection here at Melanoma Updates, it’s important to remember that “an excess of ultraviolet radiation is not only related to the appearance of melanoma, they say, it is also connected to sunburn, photoageing, many eye disorders (especially cataracts), weakness of the immune system and DNA damage.”

So, sometimes a cover-up can be the whole story.

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Nailing Skin Cancer Awareness

Thursday, August 5th, 2010

We’ve discussed being conscious of sun safety as it applies to things like over-exposure on the arm you rest on the driver’s side window or even through the windshield of your car, exposure in tanning salons, which has been all over the news lately, and even wearing hats on a regular basis.  But, per the New York Times article this week, comes a new point of diligence:  nail salons.

Picture the polish dryers so prevalent in virtually every salon; don’t they look like little tanning beds for your fingers?  Well, there’s a similarity. Apparently, they emit “similar amounts of UV radiation per meter squared, studies show. And like tanning beds, they emit predominantly UVA rays, which penetrate the skin most deeply.”

There are no definitive studies on exact correlation to skin cancer cases, but the advice given is smart:  Consider air-drying (indoors.)

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The View Offers a Better Outlook for Melanoma Screenings

Tuesday, July 6th, 2010

The NYU Post-Graduate Medical School and the highly esteemed Ronald O. Perelman Department of Dermatology, which is the first U.S. hospital to have embraced the MoleSafe method, hosted Advances in Dermatology last month for dermatologists and dermatologic surgeons and residents.  The goal of the 2-day symposium was to feature findings and lectures with an “unbiased and provocative perspective.”  For that reason, I’m particularly proud that the MoleSafe protocol and our revolutionary “View Software” was included in a morning dedicated to information on melanoma and advances in early detection.

The Right View

“View” lets physicians examine images WHILE the patient is in the office for an exam, which enables not only a more thorough exam by the doctor, but more information back to patients in real-time. [Read more in my post from November, when View was unveiled at the International Dermoscopy Society Conference.]

Previously, even with a dermatoscope, doctors reviewed only a few moles and could never be fully confident that their naked eye scrutiny discerned some of the finer, or questionable moles. For dermatologists who refer patients to MoleSafe for a comprehensive and state-of-the-art screening, this software is available for use in their offices at no charge. We just feel it is imperative to bring the opportunity for the best options for melanoma detection to as many patients as possible…and View enables a more clear, super enlarged view of all moles for doctor review, with the ability to pause on any questionable areas and compare the patient’s actual skin along side the macro images that have been delivered to the screen.

Based on the feedback we’ve gotten, this looks to be revolutionizing doctor/patient relationships and the very process of screening for  earlier detection of melanomas, especially among high risk patients.

We encourage all of our readers to review the MoleSafe web site FAQs, and to take advantage of the increasing ways and places to get the most efficacious skin cancer examination… and help us make early, accurate detection a team effort among patients, their doctors, and technology.

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What’s in a name? If it’s “ipi,” a lot!

Friday, June 11th, 2010

What’s in a name?  If it’s ipilimumab – or “ipi” for short – it may be the first name associated with prolonged life expectancy for melanoma victims.  This new immune stimulator has been making headlines recently for its early success in increasing stage four melanoma survival rates for up to four months. While that might not sounds like a lot, it’s considered highly significant. Dr. Steven O’Day of the Angeles Clinic and Research Institute in Santa Monica, Calif., a lead investigator in the recent melanoma trial explains,

This important because this is a disease where the average survival in these patients is six to nine months, so to increase on average the survival by an additional four months is a very large difference.

And though as Dr. Charles M. Balch, a melanoma expert at Johns Hopkins, said the results of the recent clinical trials are “a single, not a home run,” he added that for this disease, which impacts almost 70,000 Americans a year and growing, “even a single was important”.  As further described in The New York Times coverage of ipi,

In a study of patients who had advanced melanoma, those who got an experimental drug lived a median of about 10 months, compared with 6.4 months for those in a control group. After two years, about 23 percent of those who got the drug were alive, compared with 14 percent in the control group.

Lung cancer and melanoma are among the hardest cancers to treat. So the studies are being viewed as significant advances, though far from cures.

Dr. O’Day, who presented the research at this month’s ASCO conference, said no prior large randomized trial in melanoma has been able to demonstrate an improved survival in this type of cancer at all.  ascocover

He calls ipilimumab “the light at the end of a long, dark tunnel.”

“These results are exciting because patients with melanoma have few treatment options,” Dr. O’Day said. “After 30 years of failed studies, we finally have an option that shows a significant increase in overall survival, an endpoint that many oncology studies strive for. This new class of inhibitors that overcome T-cell suppression offers hope to melanoma patients and oncologists alike.”

The NY Times article provides a good explanation of how T-cell suppression works to possibly slow tumor growth rate though without yet being able to “put the brakes on”:

Ipilimumab is a more general immune booster. It blocks a protein called CTLA-4 that acts as a brake on T cells, the soldiers of the immune system. It is already also being tested against lung and prostate cancer.

Still, if a tumor does not elicit a strong immune response to begin with, then just keeping the response going longer would not help much, just as lifting one’s foot from the brake usually will not make a car go faster if the accelerator is not pressed.

We at MoleSafe are heartened by this news.  As always, we encourage regular and thorough screenings to provide the best line of first defense in preventing melanoma from reaching crisis status.  Please contact us at any of our now 6 clinical screening locations.

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Ooh baby, Sun protection, please!

Wednesday, June 2nd, 2010

As we mentioned in our May 6th, 2010 post The Environmental Working Group reviews sunscreens for effectiveness, eco and health-friendly levels. Their 2010 ranking was recently released (and featured on NBC newcasts this week).  Check for your brand, and possible alternatives that may be better for you, your skin and the planet.

EWG Sun Protection Summary

EWG Sun Protection Summary

The EWG list includes child-safe sunscreens as well, which is sadly a timely topic in the face of a heartbreaking news story last week: a sunbathing British mother apparently enabled her 5-month old to get severe burns over 40% of his body via lack of sun protection.  The child was hospitalized with the blistering burn, which were potentially life threatening due to side effects of dehydration and heat-stroke.

How best to protect your children? Well, NONE of us should really be sunbathing at any age, but as stated in this BBC story:

Very young children should be kept in the shade; older children, when out in the sun, should wear protective clothing including a hat, have high factor sun cream regularly applied and drink lots of fluids to stay safe and well.

In this related video from BBC News, it’s interesting to note that most of those interviewed displayed proper protection, including hats and sunglasses.  Whether England is more aware of sun dangers or they represented the conscientious minority, we all can take a page from their stylebook and cover up.

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Spotlight on Melanoma

Friday, May 14th, 2010

Some might say that celebrities are over-exposed to the spotlight.  And per our recent post on tanning, we’re seeing some celebs at least starting to minimize their over-exposure to sunlight (though sunless tans still abound), which helps raise awareness for skin cancer.  Even the the legendary Bob Marley died from a cancer whose primary source was an acral melanoma under one of his toe nails. Bob Marley

Rare but tricky to spot sometimes, Acral melanoma accounts for about 5% of all diagnosed melanomas. It is, however, one of the most common forms of melanoma in Asians and people with dark skin, accounting for up to 50% of melanomas that occur in people with these skin types. (And this is very important since recent studies have shown that Hispanics and African Americans tend to delay seeking diagnosis or treatment.)

Acral melanoma is often referred to as a “hidden melanoma” because these lesions occur on parts of the body not easily examined or not thought necessary to examine. It develops on the palms, soles, mucous membranes (such as the lining of the mouth, nose and female genitals) and underneath or near fingernails and toenails.

Here is what it usually looks like on each area of the body:

Palms of hand or soles of feet: Melanoma usually begins as an irregularly shaped tan, brown or black spot. It can be mistakenly attributed to a recent injury.

Under a nail: The first sign may be a “nail streak” – a narrow dark stripe under the nail. A new nail streak not associated with recent trauma, an enlarging nail streak, a wide or very darkly pigmented streak, or a nail that is separating or lifting up from the nail bed should be examined by a doctor.

NB: Acral melanoma can also develop without any obvious nail streak – particularly the non-pigmented variety.

Include these areas in your skin self-exams especially during a celebrity-style manicure or pedicure!

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Protecting our Planet and our Skin

Thursday, May 6th, 2010

Last month we celebrated the 40th anniversary of Earth Day. And May is Melanoma Awareness month. What do the two have in common?  Well, it’s possible to protect your planet while protecting your skin.  For our eco-conscious friends (and who isn’t more conscientious these days?) there are resources for natural sunscreens that do a good job with few, if any, chemicals.  The Environmental Working Group, a non-profit that prides itself on investigating and exposing the exact ingredients and safety levels of anything from cosmetics to pesticides, offers lists of more naturally based choices.

According to their site, and they quote an excellent story on MSNBC this week that supports the claim:

Surprisingly, 2 of 5 brand-name sunscreens either don’t protect skin from sun damage or contain hazardous chemicals — or both.  An Environmental Working Group investigation of 1,804 sunscreens rates the season’s best — and worst.

The ingredients in the product that that topped their list of “Best Sunscreens” meeting their eco and health-friendly criteria, start out with: Zinc Oxide 24.8% Grape Seed Oil, Organic Sunflower Oil, Caprylic/Capric Triglycerides (derived from Coconut Oil).  On the “Hazardous” end their list of 1800 brands investigated, the first three active ingredients often include: Octinoxate (7.5%), Octisalate (5%), Oxybenzone.

On the surface that sounds ominous, and in fact Oxybenzone has been called into question frequently, for example. However, it bears a little more reading to make an educated consumer choice – particularly a sidebar to the above story on msnbc.com, which says:

“…To get the best UVA protection, you have to be a real label hawk. Keep an eye out for these ingredients: avobenzone, Mexoryl, and zinc oxide. To be sure that avobenzone has staying power (ironically, the sun quickly renders it ineffective), it should be paired with stabilizers like octocrylene, Polyester-8, butyloctyl salicylate, or ethylhexyl methoxycrylene. (Helioplex, which is available in Neutrogena sunscreens, is a stabilized form of avobenzone.) To guard against free radicals, choose sunscreens that contain antioxidants like vitamins C (aka ascorbic acid) and E (aka tocopherol), which reduce these dangerous molecules by as much as 74%. “

No matter your product choice, it’s important to be diligent about protection, so we don’t want to discourage anyone from practicing safe sun. But since many of the natural products get their UVA/UVB blocking ability from zinc and other occluding minerals that some consumers find more difficult to apply, the EWG also created a list of alternatives that are slightly less natural, but to their team of testers and researchers, still the lesser of some evils.  ewg sunscreen guideThose products, also coded on a scale of “recommended” to “avoid”, are listed here.

Now, if you just want to see how your current brand stacks up from a chemical perspective, you can plug in the name on the EWG’s Skin Deep Cosmetic Safety Database and make your own choices that way.

Warning, some of these results may be hazardous to your peace of mind. (But remember, moderation is key in most things in life.)  I’m not endorsing or condeming any products here, but, as always, just trying to step up your awareness level and your options for caring for your skin.  So whether you opt for all natural brands, which may be healthier for the planet, too, or prefer to get your SPF from a leading brand,  one thing we DO endorse is the EWG’s responsible listing of sun safety tips.

And, whatever your choice of sunscreen is, please remember to recycle the plastic bottle it came in !

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