Archive for December, 2011

Natural Remedies For Skin Cancer?

Wednesday, December 28th, 2011

Many people these days are interested in natural or holistic medicine. It seems as though a company, ChromaDex, is attempting to find a natural answer to non- melanoma skin cancer. In an article by Peter Cleveland of SmallCap Network, ChromaDex is described as, “an innovative natural products company providing proprietary, science-based solutions and ingredients to the dietary supplement, food and beverage, cosmetic and pharmaceutical industries”.

The company is studying its pTeroPure as the potential skin cancer treatment. ChromaDex is joined by The University of California, Irvine in this endeavor. “ pTeroPure is CDXC’s ultra-pure formumation of pterostilbene, a compound found in blueberries and shown to have a number of health benefits”, says the article. The pTeroPure would target NMSC.

NMSC refers to a group of skin cancers that affect the upper layers of skin. In the U.S., NMSC is the most common form of cancer, outnumbering all other cancers combined. A number of factors are responsible for the rising incidence of NMSC, including modern addiction to sun-bathing, rising elderly population and decreasing stratospheric ozone. It is estimated that, globally, a 10% drop in the stratospheric ozone will cause 300,000 additional NMSCs.

Common treatment for NMSCs is surgery. The surgery cuts out the cancer. Another option is freezing, through which the cancer cells are frozen and destroyed. Chemotherapy and radiation treatment can also be used, but usually only when the tumors are quite large. ChromaDex is hoping that they can eliminate these treatments and their side-effects.

The idea that a compound in blueberries could cure skin cancer is quite thrilling! MoleSafe certainly hopes they’re onto something.

 

 

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The Use Of Sunless Tanning Products Lowers Tanning Bed Use

Thursday, December 22nd, 2011

A study which came out this week claims that women who use sunless tanning products are less likely to use tanning beds, USA Today reports.

Sunless tanning products are a safe alternative for people who are looking for a summer glow. They do not put people at risk for UV exposure, as does traditional sunbathing and tanning beds. The researchers found that by using the sunless products, women lowered their overall UV exposure time.

Dr. Suephy Chen pointed out that sunless tanning products offer no risk for DNA damage as well.”The product adheres to the top layer of the skin that sheds anyway”, she said. Chen believes that you can’t fight with people who want to be tan, but you can promote healthy ways to achieve that look.

For the study, Chen’s team surveyed more than 400 women, age 18 and older, about their use of sunless tanning products and their tanning habits. Almost 50 percent said they had used sunless tanning products at least once in the last year. Most had used self-applied products, with 9 percent saying they got a professionally applied spray tan. The products were used by women of all ages, the researchers noted.

Of the women used in the study, 70% said that they had tanned in the sun during the past year, 26% used tanning beds, and a quarter of the women tanned both ways. The 37% of the women who used sunless tanning products had a decrease in their amount of sun tanning.

Women who used sunless tanning products at least five times in the previous year spent 52 percent less time sunbathing, while women who used these products less often reduced sun exposure by 18 percent, the study found. Tanning bed use was reduced more than 50 percent among women who used tanning products frequently, compared with about 24 percent among women who used the tanning products less often, the researchers said.

Dr. Jonette Keri pointed out that the public  needs to get rid of the idea that a tan is healthy. Skin cancer is the fastest growing cancer in the U.S., and people need to realize this. We here at MoleSafe hope that together, with other members of the anti-melanoma community,  we can promote sun safety!

 

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Smoking Increases Risk For Squamous Cell Carcinoma In Women

Tuesday, December 13th, 2011

Researchers at Moffitt Cancer Center in Tampa, Florida have found that women with non-melanoma skin cancers are more likely to be smokers than women without these cancers.

Smoking histories were assessed and compared between patients diagnosed with BCC and/or SCC, and a group of controls comprised of patients who were screened for skin cancers, but who were not diagnosed with and had no history of skin cancer. The study’s 698 participants were recruited through Moffitt’s Lifetime Screening and Prevention Center and the University of South Florida’s Dermatology and Family Medicine Clinics. Participants were asked about their smoking behaviors in terms of years smoked, how many cigarettes per day they smoked, and when those who once smoked quit smoking. The results were stratified by sex.

The study revealed that there was a definite link between smoking and non-melanoma skin cancers for women with squamous cell carcinoma being more common than basal cell carcinoma. The risk increased with the amount of cigarettes smoked per day as well as with the amount of years a person smoked for.

The researchers concluded that:

  • Cigarette smoking was associated with non-melanoma skin cancer, and the risk increased with increasing dose (cigarettes per day) and number of years smoked.
  • Among men, smoking was modestly associated with BCC and SCC.
  • Among women, smoking was strongly associated with SCC, but not BCC.
Researchers are unclear as to why women seem to be more at risk than men, but clearly this is yet another reason to avoid smoking. We at MoleSafe hope you do!
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Blood Stem Cells Fighting Melanoma

Tuesday, December 6th, 2011

Researchers at UCLA have found that blood stem cells can be modified genetically to create cancer-fighting cells to cure melanoma. The report came out last Tuesday.

Jerome Zack led the study at the University of California Los Angeles with a team of researchers who tested lab mice. “We knew from previous studies that we could generate engineered T-cells, but would they work to fight cancer in a relevant model of human disease, such as melanoma”, Zack said in a press release.

The study found that the generated T-cells would indeed work in humans as well. The engineered cells successfully attacked the melanoma cancer cells. Researcher Dimitrios Vatakis said that,”These cells can exist in the periphery of the blood and if they detect the melanoma antigen, they can replicate to fight the cancer”.

Researchers used a T-cell receptor from a cancer patient which had been cloned. The receptor looks for an antigen determined by the type of melanoma. The human blood stem cells were created by moving genes for the T-cell receptor into the stem cell nucleus. Zee news reported that:

In the study, the engineered blood stem cells were placed into human thymus tissue that had been implanted in the mice, which allowed the research team to study the human immune system reaction to melanoma in a living organism.
Over time, about six weeks, the engineered blood stem cells developed into a large population of mature, melanoma-specific T-cells that were able to target the right cancer cells.

Two groups of mice existed, ones with the antigen complex that attracts the T-cells, and one without. The engineered T-cells successfully went for the antigen-attracting melanoma. Zack was happy to report that, “… four tumors were completely gone and the rest had regressed, both by measuring their size and actually seeing their metabolic activity through PET”.

This is hopefully the first in a long line of steps which could find a cure for melanoma. Here at MoleSafe we applaud their efforts!

 

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