About this blog...

Welcome to The Melanoma Updates Blog. This blog is intended to inform and update you on the latest developing information and technology on skin cancer prevention and detection. Dr. Bezozo, President and CEO of MoleSafe http://www.molesafe.com USA, is encouraging conversations on the topic of melanoma - the most threatening and deadliest form of skin cancer that is increasingly diagnosed each year in the U.S. Understanding first-hand how scary the disease is, Dr. B would like to hear your stories and questions about melanoma, while developing conversations that help the at-risk population manage their melanoma concerns.

*MoleSafe USA is the only early detection skin cancer system that detects melanomas up to 15 times earlier than all other traditional examinations done throughout the country.

A Majority Of Children Are Not Regularly Using Sunscreen

January 26th, 2012

A majority of children are not regularly using sunscreen, ABC News reports. These results were found by a study conducted at Memorial Sloan-Kettering Cancer Center.

360 kids who were around 10 years old between 2004 and 2007 [were] surveyed…about whether they ever had sunburns, how much time they spent in the sun and how often they wore sunscreen. The study, published in the journal Pediatrics, found that more than half the children reported having at least one sunburn the previous summer, and that number was about the same when the children were questioned three years later.

This is clearly a problem, because as we know, sunburns place you at risk for melanoma and other skin cancers. The other issue lies in the fact that good behaviors are generally reinforced in childhood, and if children are not using sunscreen now, they will likely not use it as adults either. By teaching young children the importance of sunscreen and having them use the product, it will naturally become part of their routines.  What the study also showed is that while 50% of the children said they used sunscreen at the beginning of the study, three years later only 25% of them still used it.

Stephen Duza, who led the study, pointed out that, “when you ask kids or teens about tanning, they say people look better with a tan, and tanning has a very positive association in kids of this age, so trying to get them to limit this behavior is a difficult message to get across”. Kids and teens need to see the danger in tanning, and not simply associate it with attractiveness.

Here at MoleSafe, we want to spread the importance of sun safe practices. Targeting children is most definitely one of the important steps in spreading melanoma awareness. This study is important in that it shows how much work we have yet to do. Hopefully soon we will be able to get all children to regularly wear sunscreen and understand its importance.

What do YOU think? Comment below and let us know!

 

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Zelboraf Side Effects

January 19th, 2012

Zelboraf has been hailed as a possible miracle drug for melanoma patients. Unfortunately, there may be a serious side effect which could prevent patients from taking it, USA Today is reporting.

“…roughly one-quarter of patients who take the medication develop a troublesome side effect: secondary skin cancers called squamous cell carcinomas,” the article states. Researchers at the Jonsson Comprehensive Cancer Center at the University of California: Los Angeles are looking into this new finding.  Dr. Antoni Ribas said:

What we found is that vemurafenib blocks the mutation that makes the melanoma grow, but when patients have skin cells with another mutation that’s probably induced from sun exposure, there the drug has the exact opposite effect and causes these squamous cell cancers to grow.

The findings led to what may be an even more effective way to treat melanoma, however. The researchers think that by combining vemurafenib, which is a BRAF inhibitor, with an MEK inhibitor they may be able to block the mutation, thus preventing the side effect. “It needs to be demonstrated in clinical trials, but the theory is that if we give these two medications together up front, we will be punching the melanoma where it really hurts twice, and also preventing the growth of secondary skin cancers,” said Ribas.

For the study, the researchers analyzed squamous cell lesions in patients taking vemurafenib. They were looking for genetic mutations. Out of 21 tumor samples, 13 had an RAS mutation, which places someone at risk to develop squamous cell cancer. In another set of samples 8 out of 14 had RAS mutations.

The scientists then tested mice, and were able to successfully block the growth of squamous cell cancer using BRAF and MEK inhibitors together. This experiment would obviously need to be transferred to humans so that researchers would know for sure if humans were affected.

Dr. Ribas also points out that these findings could help with other cancers as well. He said that, “what this data also warns us is that we have to be very careful about using BRAF inhibitors in a setting where we don’t know what other mutations may be driving (the cancer)”. We at MoleSafe think that they should keep up the good work!

What do YOU think? Comment below and let us know!

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Could Estrogen Cause A Recurrence Of Melanoma?

January 12th, 2012

New studies have shown that anti-estrogen therapy may help to lower the risk of melanoma, the Cancer Network reports. Medication such as Tamoxifen, which lowers estrogen amounts in the body, and has been used for breast cancer patients, may also be helping to fight melanoma.

 In a study of 7,360 women diagnosed with breast cancer between 1980 and 2005, 54% were given supplemental antiestrogen therapy. The rate of cutaneous melanoma was 60% higher for those women not taking antiestrogen supplements compared with the expected rate of melanoma incidence based on age and other factors.

The article points out that melanoma incidence varies between men and women. Women generally contract melanoma during their reproductive years, between puberty and menopause. Women also generally have a better prognosis. “Melanoma and benign nevi have been shown to express estrogen-binding receptors, and sex hormones can be associated with increased melanocyte proliferation, which is associated with early-stage melanoma. Both of these observations suggest a link between sex hormones and melanoma development”, the article stated.

As pointed out in an article on Daily  RX, these results still need to be further tested and researched. Dr. Christine Bouchardy, of the Institute for Social and Preventative Medicine at the University of Geneva, who led the study said that, “These results need to be replicated in other studies, particularly given the numerous side effects linked to this kind of drug”.  In other words, she does not think it wise for people to just assume that these anti-estrogen drugs will help melanoma.  Testing must still be done.

This is the first study which has delved into a link between melanoma and estrogen. As scientist look further into this link, they may be able to find even larger clues as to how we can beat this cancer. MoleSafe hopes they do!

What do YOU think? Leave some comments and let us know!

 

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New Year, New Skin Safety Practices

January 4th, 2012

Happy New Year! With the ushering in of 2012, we at MoleSafe decided that now was a great time to remind everyone of safe sun practices. After all, the start of a new year means new resolutions, and what better resolution is there then promising to protect your skin? Preventing skin cancer and melanoma is the first step, and while skin cancer is not 100 percent preventable, there are a lot of things that you can do to help your odds.

The Melanoma Research Foundation reminds us that, “Approximately 65 percent of melanomas—the most deadly form of skin cancer and one of the fastest growing cancers in the United States—are attributed to ultraviolet (UV) exposure from sunlight or artificial sources such as tanning beds”. They go on to say that although melanoma can develop on areas of the body not exposed to the sun, your best bet is to slather on the sunscreen. This applies to even the cloudiest of days.  Specifically they ask that we:

  • Be sure to use a sunscreen that provides broad-spectrum protection from both UVA and UVB rays and has a sun protection factor (SPF) of at least 30. Look for ingredients in your sunscreen such as titanium dioxide and mexoryl, which block UVA rays better.
  • Use enough sunscreen. To protect your entire body, use approximately an ounce of sunscreen (about a full shot glass) and apply it at least 20 minutes before sun exposure.
  • Re-apply sunscreen every two hours and after swimming or sweating, even if the bottle says it’s waterproof or long lasting.
  • Remember, wearing sunscreen is not a blank check for spending unlimited time in the sun. Sunscreen is just one component of sun safety.
Protection doesn’t end at the sunscreen however. The American Cancer Society reminds us to cover up! Slapping on a hat and sunglasses on top of sunscreen adds even one more layer of protection. Clothing can also be worn to block out some UV rays. The society reminds us to be wary however because, “If you can see light through a fabric, UV rays can get through, too. Be aware that covering up doesn’t block out all UV rays”.

We are also reminded to limit our sun exposure during the midday sun. At this time of day, the sun is at its strongest and is most harmful to us. The specific hours for this time  are between 10am and 4pm. If you are planning on spending a long amount of time outdoors during these hours, check out a UV Index to see how at risk you are.

So take these helpful tips and adapt them to your routines in this new year. We hope you have a safe and healthy 2012!
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Natural Remedies For Skin Cancer?

December 28th, 2011

Many people these days are interested in natural or holistic medicine. It seems as though a company, ChromaDex, is attempting to find a natural answer to non- melanoma skin cancer. In an article by Peter Cleveland of SmallCap Network, ChromaDex is described as, “an innovative natural products company providing proprietary, science-based solutions and ingredients to the dietary supplement, food and beverage, cosmetic and pharmaceutical industries”.

The company is studying its pTeroPure as the potential skin cancer treatment. ChromaDex is joined by The University of California, Irvine in this endeavor. “ pTeroPure is CDXC’s ultra-pure formumation of pterostilbene, a compound found in blueberries and shown to have a number of health benefits”, says the article. The pTeroPure would target NMSC.

NMSC refers to a group of skin cancers that affect the upper layers of skin. In the U.S., NMSC is the most common form of cancer, outnumbering all other cancers combined. A number of factors are responsible for the rising incidence of NMSC, including modern addiction to sun-bathing, rising elderly population and decreasing stratospheric ozone. It is estimated that, globally, a 10% drop in the stratospheric ozone will cause 300,000 additional NMSCs.

Common treatment for NMSCs is surgery. The surgery cuts out the cancer. Another option is freezing, through which the cancer cells are frozen and destroyed. Chemotherapy and radiation treatment can also be used, but usually only when the tumors are quite large. ChromaDex is hoping that they can eliminate these treatments and their side-effects.

The idea that a compound in blueberries could cure skin cancer is quite thrilling! MoleSafe certainly hopes they’re onto something.

 

 

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The Use Of Sunless Tanning Products Lowers Tanning Bed Use

December 22nd, 2011

A study which came out this week claims that women who use sunless tanning products are less likely to use tanning beds, USA Today reports.

Sunless tanning products are a safe alternative for people who are looking for a summer glow. They do not put people at risk for UV exposure, as does traditional sunbathing and tanning beds. The researchers found that by using the sunless products, women lowered their overall UV exposure time.

Dr. Suephy Chen pointed out that sunless tanning products offer no risk for DNA damage as well.”The product adheres to the top layer of the skin that sheds anyway”, she said. Chen believes that you can’t fight with people who want to be tan, but you can promote healthy ways to achieve that look.

For the study, Chen’s team surveyed more than 400 women, age 18 and older, about their use of sunless tanning products and their tanning habits. Almost 50 percent said they had used sunless tanning products at least once in the last year. Most had used self-applied products, with 9 percent saying they got a professionally applied spray tan. The products were used by women of all ages, the researchers noted.

Of the women used in the study, 70% said that they had tanned in the sun during the past year, 26% used tanning beds, and a quarter of the women tanned both ways. The 37% of the women who used sunless tanning products had a decrease in their amount of sun tanning.

Women who used sunless tanning products at least five times in the previous year spent 52 percent less time sunbathing, while women who used these products less often reduced sun exposure by 18 percent, the study found. Tanning bed use was reduced more than 50 percent among women who used tanning products frequently, compared with about 24 percent among women who used the tanning products less often, the researchers said.

Dr. Jonette Keri pointed out that the public  needs to get rid of the idea that a tan is healthy. Skin cancer is the fastest growing cancer in the U.S., and people need to realize this. We here at MoleSafe hope that together, with other members of the anti-melanoma community,  we can promote sun safety!

 

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Smoking Increases Risk For Squamous Cell Carcinoma In Women

December 13th, 2011

Researchers at Moffitt Cancer Center in Tampa, Florida have found that women with non-melanoma skin cancers are more likely to be smokers than women without these cancers.

Smoking histories were assessed and compared between patients diagnosed with BCC and/or SCC, and a group of controls comprised of patients who were screened for skin cancers, but who were not diagnosed with and had no history of skin cancer. The study’s 698 participants were recruited through Moffitt’s Lifetime Screening and Prevention Center and the University of South Florida’s Dermatology and Family Medicine Clinics. Participants were asked about their smoking behaviors in terms of years smoked, how many cigarettes per day they smoked, and when those who once smoked quit smoking. The results were stratified by sex.

The study revealed that there was a definite link between smoking and non-melanoma skin cancers for women with squamous cell carcinoma being more common than basal cell carcinoma. The risk increased with the amount of cigarettes smoked per day as well as with the amount of years a person smoked for.

The researchers concluded that:

  • Cigarette smoking was associated with non-melanoma skin cancer, and the risk increased with increasing dose (cigarettes per day) and number of years smoked.
  • Among men, smoking was modestly associated with BCC and SCC.
  • Among women, smoking was strongly associated with SCC, but not BCC.
Researchers are unclear as to why women seem to be more at risk than men, but clearly this is yet another reason to avoid smoking. We at MoleSafe hope you do!
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Blood Stem Cells Fighting Melanoma

December 6th, 2011

Researchers at UCLA have found that blood stem cells can be modified genetically to create cancer-fighting cells to cure melanoma. The report came out last Tuesday.

Jerome Zack led the study at the University of California Los Angeles with a team of researchers who tested lab mice. “We knew from previous studies that we could generate engineered T-cells, but would they work to fight cancer in a relevant model of human disease, such as melanoma”, Zack said in a press release.

The study found that the generated T-cells would indeed work in humans as well. The engineered cells successfully attacked the melanoma cancer cells. Researcher Dimitrios Vatakis said that,”These cells can exist in the periphery of the blood and if they detect the melanoma antigen, they can replicate to fight the cancer”.

Researchers used a T-cell receptor from a cancer patient which had been cloned. The receptor looks for an antigen determined by the type of melanoma. The human blood stem cells were created by moving genes for the T-cell receptor into the stem cell nucleus. Zee news reported that:

In the study, the engineered blood stem cells were placed into human thymus tissue that had been implanted in the mice, which allowed the research team to study the human immune system reaction to melanoma in a living organism.
Over time, about six weeks, the engineered blood stem cells developed into a large population of mature, melanoma-specific T-cells that were able to target the right cancer cells.

Two groups of mice existed, ones with the antigen complex that attracts the T-cells, and one without. The engineered T-cells successfully went for the antigen-attracting melanoma. Zack was happy to report that, “… four tumors were completely gone and the rest had regressed, both by measuring their size and actually seeing their metabolic activity through PET”.

This is hopefully the first in a long line of steps which could find a cure for melanoma. Here at MoleSafe we applaud their efforts!

 

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Melanoma of the Eye

November 28th, 2011

When most people think of melanoma, they think of the skin. Moles or other marks which prove to be cancerous come to mind. What many people neglect to think of, or are unaware that they should even be thinking of, are our eyes. Eyes are capable of developing melanoma.

Ocular melanoma develops because our eyes have melanin. Melanin is what produces pigment, and the cells that produce melanin can become cancerous. The Mayo Clinic points out that, “Most eye melanomas form in the part of the eye you can’t see when looking in a mirror. This makes eye melanoma difficult to detect. In addition, eye melanoma typically doesn’t cause early signs or symptoms”.

An article on Just Cancer describes the stages of the cancer. In the first stage, the melanomas have, “…approximate thickness of 1 to 2.5 mm and maximum width of 10mm”. They are small, and generally do not spread to other areas. Luckily, the chance of survival is at 84%.

In stage two the melanoma increases in size. The chance of survival also remains relatively high at 68%. What changes in this stage however, is that symptoms can begin to appear. Loss of vision, seeing spots, and seeing flashes of light are all possible.

In stage three the cancer can spread beyond the eye, but not to the lymph nodes. The symptoms are similar to those in stage 2, but the tumor is much larger at 10mm thick and 16mm in diameter. The survival rate at this stage is 47%.

At stage four, the melanoma begins to spread to other organs and the lymph nodes. There is generally appetite loss and malaise accompanied with possible loss of vision. The survival rate at this stage drops dramatically to only 15%.

So, as we can see, melanoma of the eye is very serious. As we apply our sunscreen we must also remember our sunglasses. Those with UV protection are what we at MoleSafe recommend. You can find a wide variety of shapes and colors to match your every mood!

 

 

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Americans Get On Board With Melanoma Gene Research

November 16th, 2011

Harvard Science  is reporting that a new gene mutation has been found that increses a person’s risk for malignant melanoma. As we reported back in October, groups of researchers in Australia and the UK were looking into this, and it seems as though American researchers have come to the same conclusion.

The identified mutation occurs in the gene encoding MITF, a transcription factor that induces the production of several important proteins in melanocytes, the cells in which melanoma originates.  While previous research has suggested that MITF may act as a melanoma oncogene, the current study identifies a mechanism by which MITF mutation could increase melanoma risk.

Researchers knew that MITF regulated the production of melanin, and what they found, was that this gene mutation would block the chemical change, sumoylation, which slows MITF activity. This causes MITF to overact, hence the risk for melanoma. David Fisher, the Wigglesworth Professor of Dermatology at Harvard Medical School , says that:

We now need to better understand exactly how this mutation causes melanocytes to 
become cancerous.  That information might help us discover other oncogenes as well as find treatment strategies to block the cancer-promoting activity and kill melanoma cells.

What is important to remember however, is that while 10 percent of melanoma patients report a history of the cancer in their familiy, the truly hereditary form of the cancer most likely occurs in 1 percent or less of all cases.  Hensin Tsao, of MGH Dermatology and the Wellman Center for Photomedicine, reminds us that, “most cutaneous melanomas arise as a result of interaction between environmental factors such as excessive sun exposure and more common, inherited low- to moderate-risk gene variants”.

The American study was done by sequencing the genome of a melanoma patient with a history of the cancer in their family. Melanoma was reported across three generations. The American researchers then looked into the research done by the Australians and those in the UK. What they found is that the mutation, named E318K, occurred frequently in individuals with melanoma.

Tsao says, “This MITF variant doubles the background risk for melanoma, which is approximately the same risk increase conferred by severe sunburns”. He also reminds us that what this study truly displays is the amount of collaboration researchers are willing to do in order to find an answer. Here at MoleSafe, we hope they find one soon!

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